hello there..
the difference between DDr3(1366-2400) mhz and ddr4(2100-3600) is in nanoseconds.So if u can feel a difference between 20Ns and 8 ns then yes there is a difference,but not big....
in games,you wont notice the difference.but ddr4 should be the choice as the newer cpu/mobo supports it ( ik you wont be able to use ddr3 with these xD)